J Korean Ophthalmol Soc.  2010 Jul;51(7):954-960. 10.3341/jkos.2010.51.7.954.

The Results of a Combination of Cataract Surgery and Intravitreal Bevacizumab Injection for Diabetic Macular Edema

• Kim BK
• Kweon EY
• Lee DW
• Ahn M
• Cho NC

• KMID: 2213762
• DOI: http://doi.org/10.3341/jkos.2010.51.7.954

Abstract

PURPOSE
To evaluate the efficacy and safety of the combination of cataract surgery and intravitreal bevacizumab injection in patients with cataract and diabetic macular edema.
METHODS
Patients received an intravitreal injection of bevacizumab(1.25 mg) combined with phacoemulsification and implantation of a posterior chamber intraocular lens. Best corrected visual acuity (BCVA, LogMAR) and, central macular thickness (CMT) were measured using OCT at baseline and at one week, one, three, and six months after surgery, and adverse events were recorded.
RESULTS
The mean baseline LogMAR BCVA was 0.84+/-0.50 and mean CMT was 337.1+/-57.50 micrometer. At one week, one, three, and six months after surgery, the mean BCVAs were 0.52+/-0.40, 0.51+/-0.42, 0.52+/-0.34, and 0.46+/-0.37, and the mean CMTs were 356.4+/-86.44 micrometer, 338.8+/-138.4 micrometer, 349.0+/-122.9 micrometer, and 334.2+/-100.4 micrometer, respectively. No adverse events associated with cataract surgery or intravitreal bevacizumab injection were observed.
CONCLUSIONS
The short-term results from the present study suggest the combination of cataract surgery and intravitreal bevacizumab injection are safe and effective for the prevention of macular edema aggravation for one month, but has little effect on prevention of macular edema aggravation three months after surgery for diabetic macular edema patients.

Keyword

Bevacizumab; Cataract surgery; Diabetic macular edema

MeSH Terms

Antibodies, Monoclonal, Humanized
Cataract
Humans
Intravitreal Injections
Lenses, Intraocular
Macular Edema
Phacoemulsification
Visual Acuity
Bevacizumab
Antibodies, Monoclonal, Humanized

Figure

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  Figure 1. Changes in central macular thickness with OCT after cataract surgery combined with intravitreal bevacizumab injection. CMT=central macular thickness; OCT=optical coherence tomography.

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  Figure 2. Changes in BCVA (LogMAR) after cataract surgery combined with intravitreal bevacizumab injection. BCVA=best corrected visual acuity; LogMAR=logarithm of the minimum angle of resolution.

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