J Korean Ophthalmol Soc.  2009 Jul;50(7):1005-1014. 10.3341/jkos.2009.50.7.1005.

The Effect of Preoperative Subconjunctival Injection of Mitomycin C and Triamcinolone in Recurrent Pterygium

Affiliations
  • 1Department of Ophthalmology, Kyungpook National University, School of Medicine, Daegu, Korea. okeye@hanmir.com

Abstract

PURPOSE
To evaluate the effect of a preoperative subconjunctival injection of mitomycin C or triamcinolone in patients with recurrent pterygium. METHODS: The records of 50 eyes of 50 patients who received excision of recurrent pterygium between June 2006 and January 2007 were reviewed. The recurrence rate and postoperative fibrovascular growth were compared in the preoperative subconjunctival mitomycin C, or triamcinolone injection group and non-treated control group. Additionally, the quantitative expression level of the transforming growth factor-beta1, -beta2 (TGF-beta1, -beta2), connective tissue growth factor (CTGF), and vascular endothelial growth factor (VEGF) in excised sample of the pterygium was assessed. RESULTS: There was no statistically significant difference in the recurrence rate and the relative gene expression level of growth factors in the triamcinolone group and the mitomycin group when compared with the non-treated control group. Postoperative fibrovascular proliferation was more severe in the triamcinolone group than other groups. CONCLUSIONS: Subconjunctival mitomycin C or triamcinolone as adjunctive therapy before pterygium excision did not influence the recurrence rate of pterygium.

Keyword

Adjunctive treatment; Pterygium; Mitomycin C; Subconjunctival injection; Triamcinolone

MeSH Terms

Connective Tissue Growth Factor
Eye
Gene Expression
Humans
Intercellular Signaling Peptides and Proteins
Mitomycin
Pterygium
Recurrence
Triamcinolone
Vascular Endothelial Growth Factor A
Connective Tissue Growth Factor
Intercellular Signaling Peptides and Proteins
Mitomycin
Triamcinolone
Vascular Endothelial Growth Factor A

Figure

  • Figure 1. (A) The preoperative slit lamp photograph captured by image capture system. (B) Converted image by computer program (Photoshop CS2®, Adobe sys, Inc. USA) to compare the vascularity of each pterygial tissue.

  • Figure 2. Standard Photographs classified by the pterygial thickness. (A) T1, minimal elevation with definite confirmation of episcleral vessel in most of the elevated area. (B) T2, moderate elevation, episcleral vessel can be found in some of the elevated area. (C) T3, marked elevation, episcleral vessel cannot be found because of the pterygial fleshiness.

  • Figure 3. Standard Photographs classified by the pterygial vascular proliferation. (A) V0, no directional vascular pattern. (B) V1, minimal vascularization with unidirectional pattern. (C) V2, moderate vascularization with unidirectional and enlarged vessels (D) V3, marked vascularization with unidirectional, engorged vessels.

  • Figure 4. The mRNA expression profile (mean) relative to actin mRNA expression in pterygial tissue according to the preoperative treatment (TGF-β1, −β2=transforming growth factor-β1, β2; CTGF=connective tissue growth factor; VEGF=vascular endothelial growth factor). There were no statistical difference between groups in each parameters (Mann-Whitney U test, p>0.05).


Cited by  1 articles

Autophagy of Human Tenon's Capsule Fibroblasts Induced by Mitomycin-C
Channy Park, Raekil Park, Seong Kwang Ryu, Dong Wook Lee
J Korean Ophthalmol Soc. 2011;52(11):1337-1343.    doi: 10.3341/jkos.2011.52.11.1337.


Reference

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