J Korean Ophthalmol Soc.  2008 Mar;49(3):401-408. 10.3341/jkos.2008.49.3.401.

The Short-Term Effect of Topical Cyclosporine A 0.05% in Various Ocular Surface Disorder

Affiliations
  • 1The Institute of Vision Research, Department of Ophthalmology, College of Medicine, Yonsei University, Seoul, Korea. seoky@yumc.yonsei.ac.kr

Abstract

PURPOSE: To evaluate the efficacy of topical cyclosporine A 0.05% (Restasis) in the treatment of dry eye symptoms caused by various ocular surface inflammatory disorders.
METHODS
Thirty three patients with ocular surface diseases, including 17 with Sjogren syndrome, 8 with meibomian gland dysfunction (MGD), 4 with Thygeson's keratitis, and 4 with atopic keratoconjunctivitis (AKC) were treated with Restasis twice a day for 3 months. During follow up, the symptom severity assessment (burning, itching, foreign body sensation, blurring, photophobia, and pain), TBUT (tear break up time), Schirmer score, frequencies of artificial tear use, onset of symptomatic relief, subjective satisfaction score, and side effects were evaluated.
RESULTS
In patients with Sjogren syndrome, foreign body sensation, blurring, photophobia, and pain were reduced after treatment, and the mean Schirmer score, TBUT increased and frequencies of artificial tear use decreased significantly. In patients with MGD, photophobia was reduced after treatment, TBUT and artificial tear use improved after 2 months, and the Schirmer score increased at 3 months. In patient's with Thygeson's keratitis, foreign body sensation and photophobia reduced, and the Schirmer score was increased at 3 months. No significant changes in symptoms, Schirmer score, or TBUT were observed in patients with AKC. Of all subjects, 55% reported symptomatic relief between 3 and 5 weeks after treatment. The mean satisfaction score after treatment was the highest for patients with Sjogren syndrome. Two subjects reported a temporary burning sensation, and one subject quit using Restasis because of bitter taste and a burning sensation.
CONCLUSIONS
Treatment with Restasis appeared to be effective in treating dry eye symptoms in patients with Sjogren syndrome. It was shown to be partially helpful in patients with MGD and Thygeson's keratitis, while it showed no beneficial effect in patients with AKC.

Keyword

Cycosporin A; Dry eye; Meibomian gland dysfunction; Sjogren syndrome; Thygeson keratitis
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