J Korean Soc Radiol.  2012 Apr;66(4):303-307. 10.3348/jksr.2012.66.4.303.

Cerebral Post-Transplant Lymphoproliferative Disorder Occurring after Renal Transplantation: A Case Report

  • 1Department of Radiology, College of Medicine, Yeungnam University, Daegu, Korea. wmbyun@med.yu.ac.kr


Post-transplant lymphoproliferative disorder (PTLD) is a complication of organ transplantation and immunosuppression. A 36-year-old woman with a history of renal transplantation visited the hospital complaining of headache and on pathology was diagnosed with cerebral PTLD manifesting as multiple rim enhanced masses in both hemispheres. We report here a case of post-transplant lymphoproliferative disorder involving the cerebrum occurring after renal transplantation, and describe the MRI findings for this patient.

MeSH Terms

Kidney Transplantation
Lymphoproliferative Disorders
Organ Transplantation


1. Borhani AA, Hosseinzadeh K, Almusa O, Furlan A, Nalesnik M. Imaging of posttransplantation lymphoproliferative disorder after solid organ transplantation. Radiographics. 2009. 29:981–1000. discussion 1000-1002.
2. Ho M, Jaffe R, Miller G, Breinig MK, Dummer JS, Makowka L, et al. The frequency of Epstein-Barr virus infection and associated lymphoproliferative syndrome after transplantation and its manifestations in children. Transplantation. 1988. 45:719–727.
3. Harris NL, Swerdlow SH, Frizzera G, Knowles DM. Jaffe ES, Harris NL, Stein H, Vardiman JW, editors. Posttransplant lymphoproliferative disorders. World Health Organization classification of tumours: pathology and genetics of tumors of haematopoietic and lymphoid tissues. 2001. Lyon: IARC;264–269.
4. Pickhardt PJ, Siegel MJ, Hayashi RJ, Kelly M. Posttransplantation lymphoproliferative disorder in children: clinical, histopathologic, and imaging features. Radiology. 2000. 217:16–25.
5. Castellano-Sanchez AA, Li S, Qian J, Lagoo A, Weir E, Brat DJ. Primary central nervous system posttransplant lymphoproliferative disorders. Am J Clin Pathol. 2004. 121:246–253.
6. Pickhardt PJ, Wippold FJ 2nd. Neuroimaging in posttransplantation lymphoproliferative disorder. AJR Am J Roentgenol. 1999. 172:1117–1121.
7. Loevner LA, Karpati RL, Kumar P, Yousem DM, Hsu W, Montone KT. Posttransplantation lymphoproliferative disorder of the head and neck: imaging features in seven adults. Radiology. 2000. 216:363–369.
8. Gottschalk S, Rooney CM, Heslop HE. Post-transplant lymphoproliferative disorders. Annu Rev Med. 2005. 56:29–44.
9. Miller WT Jr, Siegel SG, Montone KT. Posttransplantation lymphoproliferative disorder: changing manifestations of disease in a renal transplant population. Crit Rev Diagn Imaging. 1997. 38:569–585.
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