J Korean Pediatr Soc.  1982 Aug;25(8):781-786.

Changes in Serum Complement and Immunglonulins following Cardiopulmonary Bypass

  • 1Department of Pediatrics, Yonsei University College of Medicine, Korea.
  • 2Department of Thoracic Cardiovascular surgery, Yonsei University College of Medicine, Korea.


Clinical problem occuring in the early post operative period after cardiopulmonary bypass may ne related to the altered function of capillary bed which was affected by activation of complement system. This is so called post perfusion syndrome. We selected 20 patients with confirmed congenital heart disease by cariac catheterization. We studied the changes in the C3 , immunolglobulins, total protein, and WBC count while performing open heart surgery. The results were as followed. 1. C3 level was lowest during cardiopulmonary bypass and returned to the normal level after 8 days. 2. Each immunoglobulin level decreased just after cardiopulmonary bypass, especially the IgG level, and immunoglobulins slowly returned to the normal range after 8 days. 3. Serum total protein level and electrophoretic fractions were comperatively reduced as much as immunoglobulin levels. 4. WBC count was lower just before cardiopulmonary bypass than baseline.


Cardiopulmonary bypass; Complement system; Immunoglobulin; Oxygenator; Post perfusion syndrome; Blood gas interface
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