J Korean Pediatr Soc.  1998 May;41(5):654-662.

Acute Renal Failure in Children: Underlying Disease and Management according to Age

  • 1Department of Pediatrics, Sung Kyun Kwan University, College of Medicine.
  • 2Department of Hemodialysis Room, Sung Kyun Kwan University, College of Medicine.
  • 3Department of Pediatrics Hallym University, College of Medicine, Seoul, Korea.


PURPOSE: It has been stressed that age itself as well as multiple organ failure are important prognostic factors in acute renal failure (ARF) in children. This study was performed to find out the significance of age factor and underlying disease of ARF in children.
We tried to review 58 pediatric ARF cases, retrospectively, in the pediatric intensive care unit (excluding the neonatal and surgical intensive care unit cases) of the Samsung Seoul Hospital of Sung Kyun Kwan University from Sept., 1994. to Dec., 1996.
We classified the enrolled 58 cases into 5 age groups and more than half were younger than 1 year old. As underlying causes, heart and gastrointestinal disease were predominant in less than 1 month of age group. After 1 year of age, intrinsic renal disease was the most common cause (43-50%). Among the renal disease, systemic lupus erythematosus (10-15 year group), hemolytic uremic syndrome (1-10 year group), and obstructive uropathy (less than 1 year age group) were common etiologies. The mortality was the highest (46.7%) in less than 1 year group and lowest (21.4%) in 10-15 year age group.
The underlying disorders of ARF in children were different among the age group. Among intrinsic renal diseases, hemolytic uremic syndrome was the most common cause. The difference in the mortality was dependent on age and underlying disease.


Acute renal failure children; Age; Underlying disease; Management

MeSH Terms

Acute Kidney Injury*
Age Factors
Gastrointestinal Diseases
Hemolytic-Uremic Syndrome
Critical Care
Intensive Care Units
Lupus Erythematosus, Systemic
Multiple Organ Failure
Retrospective Studies
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