J Korean Ophthalmol Soc.  2003 Mar;44(3):755-759.

Fungal Keratitis Caused by Chromomycetes

• Kim YS
• Song YS
• Kim JC

Abstract

PURPOSE
Chromomycetes is a plant parasite and one of the pigmented filamentous fungi, which rarely causes human infection. The authors report the first case of fungal keratitis caused by chromomycetes in korea. METHODS: A 65-year-old woman developed pain, redness, and an yellowish-brown infiltrate in her right eye. She had a history of corneal scratch by a pumpkin stalk and transferred by a local clinic after management for about 1 months. The clinical features suggested fungal keratitis, and the patient was undertaken surgical debridement with amniotic membrane graft and treated with oral terbinafine with natamycin and amphotericin B eyedrops. Surgically taken biopsy specimen was cultured. Amniotic membrane was removed after 1 week. After slight improvement of symptom, necrotizing ulceration was enlarged in spite of continuous antifungal therapy. Lamellar keratoplasty with amniotic membrane graft was done with antifungal therapy. Systemic agent was changed to fluconazole. Clinical improvement was achieved after about 2 months. The fungus was identified as Fonsecaea pedrosoi. RESULTS: Fungal keratitis was successfully treated with antifungal medication combined with amniotic membrane graft. CONCLUSIONS: This is a rare case of infectious keratitis caused by chromomycetes. But its clinical course was severe, so exact culture and identification following aggressive surgical and medical treatment was needed.

Keyword

Chromoblastomycosis; Chromomycosis; Corneal ulcer; Fonsecaea Pedrosoi; Fungal Keratitis; Keratochromomycosis; Mycotic Keratitis

MeSH Terms

Aged
Amnion
Amphotericin B
Biopsy
Chromoblastomycosis
Corneal Transplantation
Corneal Ulcer
Cucurbita
Debridement
Female
Fluconazole
Fungi
Humans
Keratitis*
Korea
Natamycin
Ophthalmic Solutions
Parasites
Plants
Transplants
Ulcer
Amphotericin B
Fluconazole
Natamycin
Ophthalmic Solutions