J Korean Soc Biol Psychiatry.  1997 Nov;4(2):234-236.

Failure to Support Associations of Neurotrophin-3(NT-3) Gene Polymorphism in Korean Schizophrenic Patients

• Lee YS

Abstract

Though initial report from Japan showed positive association of schizophrenia with dinucleotide repeat polymorphism in the NT-3 gene, subsequent studies showed mixed results. Therefore we conducted a replication study with Korean schizophrenics and matched controls who share similar ethnic background with Japanese population. The frequency of allele of dinucleotide repeat at 147 base pairs in the NT-3 gene was slightly increased, however, failed to reach statistical significance(X2=1.884, df=1, p<0.170) between the two groups. These findings do not support on association of NT-3 gene polymorphism with schizophrenia in Korean sample.

MeSH Terms

Alleles
Asian Continental Ancestry Group
Base Pairing
Dinucleotide Repeats
Humans
Japan
Schizophrenia