J Korean Soc Transplant.  2014 Mar;28(1):25-35. 10.4285/jkstn.2014.28.1.25.

Analysis of 1,500 Kidney Transplantations at Sungkyunkwan University

• Hong JW
• Shin M
• Moon HH
• Lee S
• Kim JM
• Park JB
• Kwon CH
• Joh JW
• Lee SK
• Kim SJ

• KMID: 2202498
• DOI: http://doi.org/10.4285/jkstn.2014.28.1.25

Abstract

BACKGROUND
The most effective treatment for end-stage renal disease is kidney transplantation, and the number of kidney transplantations has shown a rapid increase. The aim of this study was to determine graft survival and functional outcome of 1,500 kidney transplant cases in a single center. We also investigated the factors affecting graft failure after kidney transplantation.
METHODS
We retrospectively reviewed the clinical data of 1,500 pairs of donors and subsequent recipients who underwent kidney transplantation in Samsung Medical Center, from February 1995 to January 2012.
RESULTS
The mean follow-up period was 2,241.5+/-1,609.4 days. There were 851 (56.7%) male recipients; 62 (4.1%) recipients were younger than 19 years old. Eleven (0.7%) cases were ABO blood group incompatible kidney transplant. A total of 531 (35%) deceased and 969 (65%) living donors were included. Among them, 191 (12.7%) recipients were experienced in graft failure. The most common cause of graft loss was chronic allograft nephropathy. One-year, 5-year, 10-year, and 15-year graft survival were 97.3%, 92.8%, 81.6%, and 75.1% (85.2% for living, 75.4% for deceased donor), respectively. Higher incidence of graft failure was observed in recipients who received deceased donor kidneys or experienced a rejection episode.
CONCLUSIONS
In our experience, overall 10-year graft survival after kidney transplantation was 81.6%. This report demonstrated that the type of donor (living or deceased) and history of allograft rejection are the only significant factors affecting graft survival.

Keyword

Kidney transplantation; Living donors; Deceased donor; Graft survival

MeSH Terms

Allografts
Follow-Up Studies
Graft Survival
Humans
Incidence
Kidney Failure, Chronic
Kidney Transplantation*
Kidney*
Living Donors
Male
Retrospective Studies
Tissue Donors
Transplants
Young Adult

Figure

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  Fig. 1. Number of kidney transplantation according to donor types from 1995 to 2012.

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  Fig. 2. Distribution of age (A) and gender (B) in recipients and donors.

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  Fig. 3. Relationship of donors and recipients. (A) Donor type. (B) Relationship of donor and recipients in living related kidney transplantation. (C) Relationship of donor and recipients in living unrelated kidney transplantation. (D) Donor criteria in deceased donor.

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  Fig. 4. Newly developed malignancies after kidney transplantation.

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  Fig. 5. Long-term outcomes after kidney transplantation: graft survival. (A) Overall graft survival. (B) Living donor kidney transplantation (LDKT): deceased donor kidney transplantation (DDKT) graft survival.

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  Fig. 6. Causes of graft failure after kidney transplantation.

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  Fig. 7. Long-term outcomes after kidney transplantation: patient survival. (A) Overall patient survival. (B) Living donor kidney transplantation (LDKT): deceased donor kidney transplantation (DDKT) patient survival.

Reference

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