J Korean Soc Transplant.  2005 Jun;19(1):58-62.

Effect of Cyclophosphamide as the Treatment of Recurrent Membranoproliferative Glomerulonephritis after Renal Transplantation

• Park YJ
• Kim HS
• Um HS
• Lee HY
• Choi SB
• Kim SH
• Park WD

Abstract

The treatment of recurrent type 1 membranproliferative glomerulonephritis (MPGN) after renal transplantation is undetermined yet. We report a case with a recurrent type 1 MPGN with ascites after renal transplantation that had a favorable outcome. A woman aged 50 was diagnosed recurrent type 1 MPGN in 2002. Afterwards she took cyclosporine, prednisolone and mycophenolate mofetil. Since August 2003, Her urine output was reduced and she suffered from abdominal distention. Serum creatinine was elevated to 2.5 mg/dL and physical examination and abdominal CT scan showed large amount of ascites. So, we substituted cyclophosphamide for mycophenolate mofetil. She was 55 kg before the substitution of cyclophosphamide but 12 months later, she weighed 44 kg and her creatinine decreased to 1.5 mg/dL. Therefore, it seems a good idea to use cyclophosphamide for the treatment of recurrent glomerulonephritis with ascites after renal transplantation.

Keyword

Cyclophosphamide; Recurrent type 1 membranoproliferative glomerulonephritis (MPGN); Ascites; Renal transplantation

MeSH Terms

Ascites
Creatinine
Cyclophosphamide*
Cyclosporine
Female
Glomerulonephritis
Glomerulonephritis, Membranoproliferative*
Humans
Kidney Transplantation*
Physical Examination
Prednisolone
Tomography, X-Ray Computed
Creatinine
Cyclophosphamide
Cyclosporine
Prednisolone