J Menopausal Med.  2016 Apr;22(1):50-53. 10.6118/jmm.2016.22.1.50.

Epithelioid Trophoblastic Tumor in a Postmenopausal Woman: A Case Report

• Park JW
• Bae JW

• KMID: 2200920
• DOI: http://doi.org/10.6118/jmm.2016.22.1.50

Abstract

Epithelioid trophoblastic tumor (ETT) is a rare gestational trophoblastic neoplasm composed of intermediate trophoblasts. Most cases of ETT are reported in women of reproductive age following a prior gestation within 2 weeks to 30 years. ETT is extremely rare in postmenopausal women. It is commonly misdiagnosed as a poorly differentiated carcinoma or another type of gestational trophoblastic tumor. We report a case of ETT in a 56-year-old woman that developed 23 years after the patient's last pregnancy.

Keyword

Epithelioid trophoblastic tumor; Postmenopause; Uterus

MeSH Terms

Female
Gestational Trophoblastic Disease
Humans
Middle Aged
Postmenopause
Pregnancy
Trophoblastic Neoplasms*
Trophoblasts*
Uterus

Figure

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  Fig. 1 Endometrial biopsy specimen show nodular proliferation of epithelioid trophoblasts (H&E, ×10).

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  Fig. 2 A total hysterectomy specimen showed a slightly enlarged uterus.

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  Fig. 3 The tumor showed cell necrosis with hyaline-like material, resembling squamous cell carcinoma with stromal invasion (arrow, H&E ×400).

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  Fig. 4 Immunohistochemistry showed a diffuse positive staining for placental alkaline phosphatase (PLAP) (A, ×100), P63 (B, ×100), and highly positive for Ki67 (C, ×100).

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