J Korean Soc Endocrinol.
2006 Aug;21(4):266-271. 10.3803/jkes.2006.21.4.266.
Type 2 Diabetes and Mitochondria
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- 1School of Life Sciences and Biotechnology, Korea University, Korea.
- KMID: 2200840
- DOI: http://doi.org/10.3803/jkes.2006.21.4.266
Abstract
- Liver, muscle, and adipose tissue are resistant to insulin action in type 2 diabetes. In spite of intensive studies, few diabetic genes have been identified. Recently, mitochondrial impairment has been observed in the muscle and adipose tissues of type 2 diabetes patients, implying that mitochondrial dysfunction could be a pivotal factor in type 2 diabetes. Here, we discuss mitochondrial malfunction leading to type 2 diabetes.
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