J Korean Radiol Soc.  2000 Nov;43(5):539-544. 10.3348/jkrs.2000.43.5.539.

Gadomer-17 in Contrast Enhanced MR Imaging of Reperfused Myocardial Infarction in a Cat Model

Affiliations
  • 1Department of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Soeul, Korea. thlim@www.amc.seoul.kr
  • 2NMR Laborotory, Asan Institute for Life Sciences, Korea.

Abstract

PURPOSE: To evaluate in reperfused myocardial infarction in a cat model, the time-course of signal enhancement as seen on Gadomer-17 enhanced MRI, and to correlate the size of the enhanced area with that of the infarct area as revealed by on histochemical examination.
MATERIALS AND METHODS
Five cats which had undergone occlusion of the LAD followed by reperfusion underwent MR imaging. After T2-weighted imaging, Gadomer-17 enhanced T1-weighted images were obtained in four cats during a six-hour period, and in one during a three-hour period. Signal intensities were measured in the enhanced and non-enhanced areas of enhanced T1-weighted images. and using 2,3,5-triphenyl tetrazolium chloride (TTC) histochemical staining, the size of the abnormal signal area on each image was compared with that of the infarct area. RESULT: The enhanced area seen on enhanced T1-weighted images showed rapidly increased signal intensity following the administration of Gadomer-17. Maximum enhancement was detected during a 40 -60 minutes period, with an average enhancement of 168 +/-9.9% of normal myocardium. TTC staining revealed that the size of the high signal area on T2-weighted images and of the enhanced area on enhanced T1-weighted images was greater than that of the infarct area (p<0.05).
CONCLUSION
In reperfused myocardial infarction in a cat model, Gadomer-17 enhanced MR imaging delineates both reversibly and irreversibly damaged myocardium, with strong enhancement and a broad temporal window. We may therefore expect that Gadomer-17 is useful for demonstrating myocardial injury.

Keyword

Myocardium, infarction; Magnetic resonance (MR), contrast agent
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