J Korean Soc Endocrinol.
2002 Aug;17(4):603-609.
A Case of AVP Dependent Bilateral Macronodular Adrenal Hyperplasia
- Affiliations
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- 1Department of Internal Medicine, Yonsei University, College of Medicine, Seoul, Korea.
- 2Department of Pathology, Yonsei University, College of Medicine, Seoul, Korea.
Abstract
- Adrenocorticotropin (ACTH) independent bilateral macronodular adrenal hyperplasia (AIMAH) is a rare form of Cushing's syndrome, in which unique endocrinological, clinical and histopathological features have been described. In AIMAH, cortisol secretion is autonomous and independent of ACTH, thus plasma ACTH levels are persistently suppressed. Various etiological mechanisms have been proposed to explain the development of AIMAH, the development of aberrant adrenal sensitivity to gastric inhibitory polypeptide (GIP), vasopressin, beta-adrenergic receptor agonists or the presence of circulating adrenal stimulating immunoglobulins have been suggested. We report on a 46-year-old female who had Cushing's syndrome, due to AIMAH, with a positive response to vasopressin.
MeSH Terms
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Adrenergic beta-Agonists
Adrenocorticotropic Hormone
Cushing Syndrome
Female
Gastric Inhibitory Polypeptide
Humans
Hydrocortisone
Hyperplasia*
Immunoglobulins
Middle Aged
Plasma
Vasopressins
Adrenergic beta-Agonists
Adrenocorticotropic Hormone
Gastric Inhibitory Polypeptide
Hydrocortisone
Immunoglobulins
Vasopressins
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