J Korean Soc Pediatr Nephrol.  2008 Oct;12(2):250-255.

A Case of Diabetic Nephropathy in a Child with Type 1 Diabetes

• Jung HH
• Park SS
• Kim SD
• Cho BS

Abstract

Diabetes mellitus(DM) is a metabolic syndrome caused by deficiency of insulin secretion and a consequence of insulin resistance. Poor glycemic control is a common finding in children with Type 1 DM(T1DM). Approximately 60% of the young patients with T1DM develop abnormalities in the eyes and 15-20% in the kidney. Diabetic nephropathy (DN) is a serious metabolic complication of T1DM that leads to renal failure. Some clinical studies report that the duration of prepubertal diabetes may contribute less to the development of microvascular complications than pubertal and postpubertal duration. There have been few cases of DN in prepubertal patients with T1DM in Korea. Thus we report a case of a 12-year-old female with T1DM who had poor glycemic control and was diagnosed as DN in a prepubertal period. It was proven by renal biopsy after microscopic hematuria and proteinuria were detected through the mass school urinary screening program.

Keyword

Diabetic nephropathy; Children; Type 1 DM; Prepubertal duration

MeSH Terms

Biopsy
Child
Diabetic Nephropathies
Eye
Female
Hematuria
Humans
Insulin
Insulin Resistance
Kidney
Korea
Mass Screening
Proteinuria
Renal Insufficiency
Insulin