J Korean Soc Pediatr Nephrol.  2008 Oct;12(2):250-255.

A Case of Diabetic Nephropathy in a Child with Type 1 Diabetes

Affiliations
  • 1Department of Pediatrics, College of Medicine, Kyunghee University, Seoul, Korea. bscho@dreammmwiz.com
  • 2East West Kidney Diseases Research Institute, Kyunghee University, Seoul, Korea.

Abstract

Diabetes mellitus(DM) is a metabolic syndrome caused by deficiency of insulin secretion and a consequence of insulin resistance. Poor glycemic control is a common finding in children with Type 1 DM(T1DM). Approximately 60% of the young patients with T1DM develop abnormalities in the eyes and 15-20% in the kidney. Diabetic nephropathy (DN) is a serious metabolic complication of T1DM that leads to renal failure. Some clinical studies report that the duration of prepubertal diabetes may contribute less to the development of microvascular complications than pubertal and postpubertal duration. There have been few cases of DN in prepubertal patients with T1DM in Korea. Thus we report a case of a 12-year-old female with T1DM who had poor glycemic control and was diagnosed as DN in a prepubertal period. It was proven by renal biopsy after microscopic hematuria and proteinuria were detected through the mass school urinary screening program.

Keyword

Diabetic nephropathy; Children; Type 1 DM; Prepubertal duration
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