J Korean Med Assoc.  2013 Apr;56(4):271-278. 10.5124/jkma.2013.56.4.271.

Procedural sedation and analgesia in children

Affiliations
  • 1Department of Anesthesiology and Pain Medicine, Inha University College of Medicine, Incheon, Korea. jhs@inha.ac.kr

Abstract

As various diagnostic and treatment technologies evolve, the performance of diagnostic and therapeutic procedures on pediatric patients outside operating rooms is rapidly becoming more common. Procedural sedation and analgesia refers to the use of sedatives and analgesics to provide anxiolysis, analgesia, and immobilization during the procedure. There is a need for a common guideline that may be used by different health professionals, including anesthesiologists, pediatricians, emergency medicine physicians, dentists, radiologists, and others that are involved in these settings. Furthermore, during the entire process an anesthesiologist should be responsible for the training of those involved. Procedural sedation and analgesia is a branch of clinical medicine that includes informed consent, fasting before sedation, patient evaluation, medication administration, patient monitoring, recovery and discharge, and cardiopulmonary resuscitation. Complications associated with procedural sedation and analgesia may occur due to a drug overdose or side effects, inadequate patient monitoring, physician's errors, and/or insufficient recovery. Although the most common complications are airway obstruction or respiratory depression, these may be prevented by careful patient monitoring and appropriate emergency response. Further progress in procedural sedation and analgesia will require research, an assessment of newer sedatives, and improvements in the reporting system for adverse events.

Keyword

Child; Conscious sedation; Deep sedation; Complications

MeSH Terms

Airway Obstruction
Analgesia
Analgesics
Cardiopulmonary Resuscitation
Child
Clinical Medicine
Conscious Sedation
Deep Sedation
Dentists
Drug Overdose
Emergencies
Emergency Medicine
Fasting
Health Occupations
Humans
Hypnotics and Sedatives
Immobilization
Informed Consent
Monitoring, Physiologic
Operating Rooms
Respiratory Insufficiency
Analgesics
Hypnotics and Sedatives

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Reference

1. Consensus conference. Anesthesia and sedation in the dental office. JAMA. 1985. 254:1073–1076.
2. Committee on Drugs. Section on anesthesiology. Guidelines for the elective use of conscious sedation, deep sedation, and general anesthesia in pediatric patients. Pediatrics. 1985. 76:317–321.
3. Green SM, Krauss B. Procedural sedation terminology: moving beyond "conscious sedation". Ann Emerg Med. 2002. 39:433–435.
Article
4. Committee on Drugs, American Academy of Pediatrics. Guidelines for monitoring and management of pediatric patients during and after sedation for diagnostic and therapeutic procedures: addendum. Pediatrics. 2002. 110:836–838.
5. American Society of Anesthesiologists Task Force on Sed-ation and Analgesia by Non-Anesthesiologists. Practice guidelines for sedation and analgesia by non-anesthesiologists. Anesthesiology. 2002. 96:1004–1017.
6. Godwin SA, Caro DA, Wolf SJ, Jagoda AS, Charles R, Marett BE, Moore J. American College of Emergency Physicians. Clinical policy: procedural sedation and analgesia in the emer-gency department. Ann Emerg Med. 2005. 45:177–196.
Article
7. Joint Commission on Accreditation of Healthcare Organizations. Comprehensive accreditation manual for hospitals. 2005. Oakbrook Terrace: Joint Commission on Accreditation of Healthcare Organizations.
8. Korea Institute for Healthcare Accreditation. Guidebook for healthcare accreditation ver. 1.2. 2011. Seoul: Korea Institute for Healthcare Accreditation.
9. Practice guidelines for preoperative fasting and the use of pharmacologic agents to reduce the risk of pulmonary aspira-tion: application to healthy patients undergoing elective procedures: a report by the American Society of Anesthesiologist Task Force on Preoperative Fasting. Anesthesiology. 1999. 90:896–905.
10. Green SM, Krauss B. Pulmonary aspiration risk during emergency department procedural sedation: an examination of the role of fasting and sedation depth. Acad Emerg Med. 2002. 9:35–42.
Article
11. Roback MG, Bajaj L, Wathen JE, Bothner J. Preprocedural fasting and adverse events in procedural sedation and analgesia in a pediatric emergency department: are they related? Ann Emerg Med. 2004. 44:454–459.
Article
12. Cravero JP, Blike GT, Beach M, Gallagher SM, Hertzog JH, Havidich JE, Gelman B. Pediatric Sedation Research Consor-tium. Incidence and nature of adverse events during pediatric sedation/anesthesia for procedures outside the operating room: report from the Pediatric Sedation Research Consortium. Pediatrics. 2006. 118:1087–1096.
Article
13. Cravero JP, Beach ML, Blike GT, Gallagher SM, Hertzog JH. Pediatric Sedation Research Consortium. The incidence and nature of adverse events during pediatric sedation/anesthesia with propofol for procedures outside the operating room: a report from the Pediatric Sedation Research Consortium. Anesth Analg. 2009. 108:795–804.
Article
14. Tait AR, Malviya S. Anesthesia for the child with an upper respiratory tract infection: still a dilemma? Anesth Analg. 2005. 100:59–65.
Article
15. Deitch K, Miner J, Chudnofsky CR, Dominici P, Latta D. Does end tidal CO2 monitoring during emergency department procedural sedation and analgesia with propofol decrease the incidence of hypoxic events?: a randomized, controlled trial. Ann Emerg Med. 2010. 55:258–264.
Article
16. Qadeer MA, Vargo JJ, Dumot JA, Lopez R, Trolli PA, Stevens T, Parsi MA, Sanaka MR, Zuccaro G. Capnographic monitoring of respiratory activity improves safety of sedation for endoscopic cholangiopancreatography and ultrasonography. Gastroenterology. 2009. 136:1568–1576.
Article
17. Powers KS, Nazarian EB, Tapyrik SA, Kohli SM, Yin H, van der Jagt EW, Sullivan JS, Rubenstein JS. Bispectral index as a guide for titration of propofol during procedural sedation among children. Pediatrics. 2005. 115:1666–1674.
Article
18. Boswinkel JP, Litman RS. Sedating patients for radiologic studies. Pediatr Ann. 2005. 34:650–654. 656
Article
19. Boswinkel JP, Litman RS. The pharmacology of sedation. Pediatr Ann. 2005. 34:607–613.
Article
20. Mayers DJ, Hindmarsh KW, Gorecki DK, Sankaran K. Sedative/hypnotic effects of chloral hydrate in the neonate: trichloroethanol or parent drug? Dev Pharmacol Ther. 1992. 19:141–146.
Article
21. Massanari M, Novitsky J, Reinstein LJ. Paradoxical reactions in children associated with midazolam use during endoscopy. Clin Pediatr (Phila). 1997. 36:681–684.
Article
22. Kain ZN, Hofstadter MB, Mayes LC, Krivutza DM, Alexander G, Wang SM, Reznick JS. Midazolam: effects on amnesia and anxiety in children. Anesthesiology. 2000. 93:676–684.
23. Spear RM, Yaster M, Berkowitz ID, Maxwell LG, Bender KS, Naclerio R, Manolio TA, Nichols DG. Preinduction of anesthesia in children with rectally administered midazolam. Anesthesiology. 1991. 74:670–674.
Article
24. Wilton NC, Leigh J, Rosen DR, Pandit UA. Preanesthetic sedation of preschool children using intranasal midazolam. Anesthesiology. 1988. 69:972–975.
Article
25. Veldhoen ES, Hartman BJ, van Gestel JP. Monitoring biochemical parameters as an early sign of propofol infusion syndrome: false feeling of security. Pediatr Crit Care Med. 2009. 10:e19–e21.
Article
26. Ross AK, Davis PJ, Dear G, Ginsberg B, McGowan FX, Stiller RD, Henson LG, Huffman C, Muir KT. Pharmacokinetics of remifentanil in anesthetized pediatric patients undergoing elective surgery or diagnostic procedures. Anesth Analg. 2001. 93:1393–1401.
Article
27. Komatsu H, Taie S, Endo S, Fukuda K, Ueki M, Nogaya J, Ogli K. Electrical seizures during sevoflurane anesthesia in two pediatric patients with epilepsy. Anesthesiology. 1994. 81:1535–1537.
Article
28. Wilson RD, Traber DL, Evans BL. Correlation of psychologic and physiologic observations from children undergoing repeated ketamine anesthesia. Anesth Analg. 1969. 48:995–1001.
Article
29. Gutstein HB, Johnson KL, Heard MB, Gregory GA. Oral ketamine preanesthetic medication in children. Anesthesiology. 1992. 76:28–33.
Article
30. Aouad MT, Moussa AR, Dagher CM, Muwakkit SA, Jabbour-Khoury SI, Zbeidy RA, Abboud MR, Kanazi GE. Addition of ketamine to propofol for initiation of procedural anesthesia in children reduces propofol consumption and preserves hemodynamic stability. Acta Anaesthesiol Scand. 2008. 52:561–565.
Article
31. Slavik VC, Zed PJ. Combination ketamine and propofol for procedural sedation and analgesia. Pharmacotherapy. 2007. 27:1588–1598.
Article
32. Mahmoud M, Gunter J, Donnelly LF, Wang Y, Nick TG, Sadhasivam S. A comparison of dexmedetomidine with propofol for magnetic resonance imaging sleep studies in children. Anesth Analg. 2009. 109:745–753.
Article
33. Mason KP, Zurakowski D, Zgleszewski SE, Robson CD, Carrier M, Hickey PR, Dinardo JA. High dose dexmedetomidine as the sole sedative for pediatric MRI. Paediatr Anaesth. 2008. 18:403–411.
Article
34. Heard C, Burrows F, Johnson K, Joshi P, Houck J, Lerman J. A comparison of dexmedetomidine-midazolam with propofol for maintenance of anesthesia in children undergoing magnetic resonance imaging. Anesth Analg. 2008. 107:1832–1839.
Article
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