J Korean Neurosurg Soc.  2016 May;59(3):192-196. 10.3340/jkns.2016.59.3.192.

Development and Growth of the Normal Cranial Vault : An Embryologic Review

• Jin SW
• Sim KB
• Kim SD

• KMID: 2192084
• DOI: http://doi.org/10.3340/jkns.2016.59.3.192

Abstract

Understanding the development of a skull deformity requires an understanding of the normal morphogenesis of the cranium. Craniosynostosis is the premature, pathologic ossification of one or more cranial sutures leading to skull deformities. A review of the English medical literature using textbooks and standard search engines was performed to gather information about the prenatal development and growth of the cranial vault of the neurocranium. A process of morphogenic sequencing begins during prenatal development and growth, continues postnatally, and contributes to the basis for the differential manner of growth of cranial vault bones. This improved knowledge might facilitate comprehension of the pathophysiology of craniosynostosis.

Keyword

Cranial sutures; Craniosynostosis; Embryonic development; Growth; Skull

MeSH Terms

Comprehension
Congenital Abnormalities
Cranial Sutures
Craniosynostoses
Embryonic Development
Female
Growth and Development*
Morphogenesis
Ossification, Heterotopic
Pregnancy
Search Engine
Skull

Figure

• 

  Fig. 1 Skeletal structure of skull : mesenchyme for these structures is derived from neural crest (white) and paraxial mesoderm (gray). Sq : squamous, Pet : petrous.

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