J Korean Neurol Assoc.  2014 May;32(2):98-102.

Logopenic Progressive Aphasia Revealing Positive Cerebrospinal Fluid Biomarkers for Alzheimer's Disease

Affiliations
  • 1Department of Neurology, Soonchunhyang University Hospital, Soonchunhyang University College of Medicine, Bucheon, Korea. sapark@schmc.ac.kr
  • 2Department of Anesthesiology, Soonchunhyang University Hospital, Soonchunhyang University College of Medicine, Bucheon, Korea.

Abstract

Primary progressive aphasia (PPA) is classified into agrammatic, semantic, and logopenic variants, but differential diagnosis is often challenging. There is accumulating evidence that the neuropathology of logopenic PPA is distinct from that of the other types. We report herein a woman with logopenic PPA who was diagnosed by clinical, neuropsychological, and radiologic data during 2 years of follow-up. Interestingly, her cerebrospinal fluid biomarkers were found to be similar to those found in Alzheimer's disease, with a decreased concentration of Abeta42 and an increased concentration of pTau181 (tTau).

Keyword

Biomarker; Cerebrospinal fluid; Logopenic aphasia

MeSH Terms

Alzheimer Disease*
Aphasia*
Aphasia, Primary Progressive
Biomarkers*
Cerebrospinal Fluid*
Diagnosis, Differential
Female
Follow-Up Studies
Humans
Semantics
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