J Korean Neurol Assoc.  2014 May;32(2):91-94.

Steroid Responsive Recurrent Limbic Encephalitis Associated With LGI1 Antibodies

Affiliations
  • 1Department of Neurology, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Yangsan, Korea. jhlee.neuro@pusan.ac.kr

Abstract

Limbic encephalitis (LE) is characterized by short-term memory loss, disorientation, agitation, seizures, and histological evidence of mesial temporal lobe inflammation. Leucine-rich, glioma inactivated 1 (LGI1) is the autoantigen associated with limbic encephalitis that was previously attributed to voltage-gated potassium channels. We report herein a 54-year-old female with LGI1-related limbic encephalitis who presented with recurrent episodes of episodic memory impairment, depressive mood, and phantosmia. Her symptoms dramatically improved with steroid therapy.

Keyword

LGI1 encephalitis; Limbic encephalitis

MeSH Terms

Antibodies*
Dihydroergotamine
Female
Glioma
Humans
Inflammation
Limbic Encephalitis*
Memory, Episodic
Memory, Short-Term
Middle Aged
Potassium Channels, Voltage-Gated
Seizures
Temporal Lobe
Antibodies
Dihydroergotamine
Potassium Channels, Voltage-Gated
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