J Korean Orthop Assoc.  2002 Oct;37(5):649-653.

Skeletal Manifestation of Paget's Disease in Korean

Affiliations
  • 1Department of Orthopaedic Surgery, College of Medicine, The Catholic University of Korea, Seoul, Korea. ykang@vincent.cuk.ac.kr
  • 2Department of Clinical Pathology, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Abstract

PURPOSE: We reviewed the clinical characteristics of skeletal Paget's disease in Korean.
MATERIALS AND METHODS
We retrospectively analyzed the clinical features, the responses to treatment and complications of 11 cases of Paget's disease occurred in Korean patients. Then we compared the result obtained with those previously reported.
RESULTS
Previous studies have mainly involved the axial skeleton, such as skull, spine or pelvic bone, and the pelvis was the most commonly involved site. In 7 cases, more than one site were involved. Clinical symptoms were pain around the involved sites in 5 cases and claudica-tion associated with spinal stenosis in one case. Serum alkaline phosphatase, a biochemical marker of bone formation, was elevated two to five fold in all cases. Responding to bisphosphate, the clinical symptoms subsided and the levels of alkaline phosphatase were markedly diminished or normalized. No serious complications, such as, cranial neuropathy or a congestive heart failure occurred.
CONCLUSION
Compared western reports, Paget's disease of skeletal bone in Koreans showed a much lower incidence rate, milder symp-toms and fewer complications.

Keyword

Paget's disease

MeSH Terms

Alkaline Phosphatase
Biomarkers
Cranial Nerve Diseases
Heart Failure
Humans
Incidence
Osteogenesis
Pelvic Bones
Pelvis
Retrospective Studies
Skeleton
Skull
Spinal Stenosis
Spine
Alkaline Phosphatase
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