J Korean Soc Osteoporos.
2010 Apr;8(1):26-37.
Effects of Combined Estrogen and Effervescent Fluocalcic Therapy on the Bone Mineral Density and Bone Metabolism of Surgical Menopause Women with Osteopenia
- Affiliations
-
- 1Department of Obstetrics and Gynecology, College of Medicine, Inje University, Seoul, Korea.
- 2Department of Obstetrics and Gynecology, College of Medicine, Kyung Hee University, Seoul, Korea.
- 3Department of Family Medicine, College of Medicine, Kwandong University, Seoul, Korea.
- 4Department of Family Medicine, College of Medicine, Kosin University, Busan, Korea.
- 5Department of Obstetrics and Gynecology, College of Medicine, Kosin University, Busan, Korea. hykyale@yahoo.com
- 6Department of Obstetrics and Gynecology, College of Medicine, Konkuk University, Seoul, Korea.
Abstract
OBJECTIVE
To evaluate the effects of estrogen therapy and fluocalcic on the bone mineral density and bone metabolism in surgically menopausal osteopenic women.
METHODS
This prospective randomized clinical trial examined the effects of conjugated equine estrogen and fluocalcic in combination and separately, on bone mass density (BMD) and biochemical markers of bone turnover in 200 women with low bone mass. Treatment included 1 mg estradiol (Group I, n=50), 2 mg estradiol (Group II, n=50), 1 mg estradiol plus fluocalcic (Group III, n=50), and 2 mg estradiol plus fluocalcic (Group IV, n=50) for 12 months. Bone density measurements were performed at 6 and 12 months at the lumbar spine and femur neck. Biochemical markers of bone turnover were also measured every 6 months.
RESULTS
The BMD of the lumbar spine increased significantly during the treatment in Group III and Group IV (P<0.05), while the BMD of the femur neck increased slightly, but not significantly, during treatment in all groups. In addition, urinary deoxypyridinoline decreased significantly in Group III and Group IV at 12 months of treatment (P<0.005). On the other hand, serum osteocalcin and total alkaline phosphatase decreased slightly, but not significantly, in all groups during the treatment.
CONCLUSION
The combined treatment with estradiol and fluocalcic is more effective in surgically menopausal women with osteopenia because it decreases bone biochemical markers and increases BMD.
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