J Korean Geriatr Psychiatry.  2015 Oct;19(2):97-100. 10.0000/jkgp.2015.19.2.97.

Reduced Cortical Thickness in Patients with Late Life Depression without Cerebral Vascular Disease

Affiliations
  • 1Department of Psychiatry, Pusan National University Hospital, Busan, Korea. psyleekr@naver.com
  • 2Medical Research Institute, Pusan National University Hospital, Busan, Korea.
  • 3Department of Psychiatry, Yangsan Pusan National University Hospital, Yangsan, Korea.

Abstract


OBJECTIVES
The aim of this study is to compare cortical thickness in late life major depression patients without cerebral vascular disease (CVD) with that of non-depressed normal comparison subjects using magnetic resonance imaging (MRI).
METHODS
Altogether, 47 subjects were finally recruited from the Memory impairment clinics of Pusan National University Hospital in Korea. All subjects (late life major depression patients without CVD : n=21, matched non-depressed normal comparison subjects : n=26) underwent 3-tesla MRI.
RESULTS
Late life major depression patients without CVD showed reduced cortical thickness in left precuneus, left inferior temporal gyrus, and left cuneus compared with non-depressed normal comparison subjects.
CONCLUSION
Our findings suggest that late life major depression without CVD is associated with reduced cortical thickness.

Keyword

Late life major depression; Cortical thickness; Magnetic resonance imaging
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