J Korean Neurol Assoc.  2001 Mar;19(2):170-172.

Dysarthria after Donepezil

Affiliations
  • 1Department of Neurology, Kyunggi Provincial Hospital For The Elderly.

Abstract

We report a case of speech disturbance as an unrecognized adverse effect of the selective acetylcholinesterase inhibitor, donepezil. A 79-year-old woman presented with progressive memory disturbance that began 3 years ago. A brain MRI and neuropsychological test suggested that she had Alzheimer's disease. She showed transient dysarthria 14 days after the initiation of donepezil. Isolated speech disturbances were not observed. Clinicians should be alert to the possibility of dysarthria as an adverse effect of donepezil. (J Korean Neurol Assoc 19(2):170~172, 2001)

Keyword

Alzheimer's disease; Donepezil; Dysarthria

MeSH Terms

Acetylcholinesterase
Aged
Alzheimer Disease
Brain
Dysarthria*
Female
Humans
Magnetic Resonance Imaging
Memory
Neuropsychological Tests
Acetylcholinesterase
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