J Korean Neurol Assoc.  2009 May;27(2):129-135.

Impact of Obstructive Sleep Apnea on Carotid Intima-Media Thickness

Affiliations
  • 1Department of Neurology, College of Medicine, Inha University, Incheon, Korea. ych333@chol.com

Abstract

BACKGROUND: Obstructive sleep apnea (OSA) is known to be an independent risk for cardiovascular diseases. The carotid intima.media thickness (IMT) is a surrogate marker of subclinical atherosclerosis. The aim of this study was to measure the carotid IMT in subjects with or without OSA and quantify its correlation with OSA severity.
METHODS
Subjects were categorized into OSA and non-OSA groups based on polysomnography findings. The carotid IMT was considered a marker of atherosclerosis. The independent relationship between carotid IMT and OSA severity was analyzed using multiple linear regression. The presumed confounders were age, sex, body mass index, blood pressure, blood lipid and glucose profiles, smoking and alcohol drinking statuses, medications, being overweight, and having hypertension, diabetes mellitus, or hyperlipidemia.
RESULTS
The carotid IMT was larger in OSA subjects (n=82, 0.620+/-0.096 mm [mean+/-SD]) than in non-OSA subjects (n=22, 0.551+/-0.078 mm; p=0.006), and was independently correlated with OSA severity (p<0.001). However, it was not affected by any of the other variables investigated.
CONCLUSIONS
Subjects with OSA showed an increased IMT, with the thickness being correlated with the OSA severity. This finding suggests that accelerated atherosclerosis in OSA is the mechanism linking OSA and future cardiovascular events.

Keyword

Carotid artery; Hypoxia; Doppler ultrasonography

MeSH Terms

Alcohol Drinking
Anoxia
Atherosclerosis
Biomarkers
Blood Pressure
Body Mass Index
Cardiovascular Diseases
Carotid Arteries
Carotid Intima-Media Thickness
Diabetes Mellitus
Glucose
Hypertension
Linear Models
Overweight
Polysomnography
Sleep Apnea, Obstructive
Smoke
Smoking
Ultrasonography, Doppler
Glucose
Smoke
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