J Korean Med Assoc.
2004 Oct;47(10):940-947. 10.5124/jkma.2004.47.10.940.
Neural Stem Cells for Neurological Disorders
- Affiliations
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- 1Stroke and Neural Stem Cell Laboratory in Clinical Research Institute, Department of Neurology, Seoul National University College of Medicine and Hospital, Korea. rohjk@snu.ac.kr, kimmanho@snu.ac.kr, stemgen1@snu.ac.kr
- KMID: 2183531
- DOI: http://doi.org/10.5124/jkma.2004.47.10.940
Abstract
- Recent progress shows that neurons suitable for transplantation can be generated from neural stem cells (NSCs) in culture, and that the adult brain produces new neurons from its own stem cells in response to injury. In this article, we discuss how the subventricular zone of the forebrain is the most active neurogenetic area and the richest source of NSCs. This review also focuses on the nature and functional properties of NSCs of the adult mammalian brain, and we propose our views on the strategy from bench to the clinic with particular concerns and considerations.
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