J Korean Med Assoc.  2004 Apr;47(4):334-341. 10.5124/jkma.2004.47.4.334.

Revolutionary Concept on Aging and Functional Longevity

  • 1The Aging and Apoptosis Research Center, Seoul National University College of Medicine, Korea. scpark@snu.ac.kr


The rapid increase of the elderly population has generated unprecedented social and cultural conflicts. One of the fundamental factors underlying these turbulences would be the traditional concept on aging and the elderly, which has been prevailed by the negative view as an irreversible and inevitable process. However, the recent researches have revealed that aging is a biological process not for death but for survival, suggesting a responsive and adaptive aspect of being aging. This revolutionary change in the concept on aging may provoke aconfident aspect of aging, leading to a more productive and active participation of the elderly in the community. Therefore, the traditional view on aging, as a functionally deteriorated and morphologically altered state of the organism, should be corrected. Based on this new concept, the policy and strategy for the future society should be replanned. Moreover, the elderly individuals should try to maintain the best condition toward the functional longevity without despair or discourage. In this article, I briefly introduce the novel hypothesis on aging, that is, "The Gate Theory of Aging", and discuss the replace vs restore principles for aging control.


Functional longevity; Replace; Restore; Gate therapy; Aging

MeSH Terms

Biological Processes


3. Cho KA, Ryu SJ, Park JS, Jang IS, Ahn JS, Park SC. Senescent phenotype can be reversed by reduction of caveolin status. J Biol Chem. 2003. 278:27789–27795.
4. Park SC. Functional recovery of senescent cells through restoration of receptor-mediated endocytosis. Mech Ageing Dev. 2003. 123(8):917–925.
5. Park JS, Park WY, Cho KA, Kim DI, Jhun BH, Park SC. Down-regulation of amphiphysin-1 is responsible for reduced receptor-mediated endocytosis in the senescent cells. FASEB J. 2001. 15:1625–1627.
6. Park WY, Park JS, Cho KA, Kim DI, Ko YG, Park SC. Up-regulation of caveolin attenuates epidermal growth factor signdling in senescent cells. J Biol Chem. 2000. 275:20847–20852.
7. Suh Y, Lee KA, Kim WH, Han BG, Vijg J, Park SC. Aging alters the apoptotic response to genotoxic stress. Nature Medicine. 2002. 8(1):3–4.
8. Yeo EJ, Hwang YC, Kang CM, Choy HE, Park SC. Reduction of UV-induced cell death in the human senescent fibroblasts. Mol Cells. 2002. 10(4):415–412.
9. Yeo EJ, Park SC. Age dependent agonist-specific dysregulation of membrane-mediated signal transduction; emergence of the gate theory of aging. Mech Ageing Dev. 2002. 123:1563–1567.
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