J Korean Diabetes Assoc.  2007 Nov;31(6):507-516. 10.4093/jkda.2007.31.6.507.

The Plasma Adiponectin Levels in Patients with Newly Diagnosed Type 2 Diabetes

• Lee IS
• Kim YJ
• Kim JI
• Park JH
• Ku BJ
• Park KS
• Lee TY
• Kim YK

• KMID: 2177564
• DOI: http://doi.org/10.4093/jkda.2007.31.6.507

Abstract

BACKGROUND: Adiponectin is secreted from adipose tissue and plays an important role in the regulation of glycemia and insulin resistance. In this study, the relationship between adiponectin and the adiposity, body composition, insulin sensitivity, lipid profile were respectively examined in newly diagnosed type 2 diabetes.
METHODS
Total 1993 were participated in the Korea Rural Genomic Cohort Study (Geumsan County). After a 12-hour overnight fast, all subjects underwent 75-g oral glucose tolerance test. 105 of those were studied as newly diagnosed type 2 diabetes. The body composition was analyzed by means of bioelectric impedance analysis and the insulin sensitivity was estimated by fasting insulin, HOMA-IR and QUICKI method, respectively.
RESULTS
Adiponectin positively correlated with high-density lipoprotein cholesterol (r = 0.246, P < 0.05). Adiponectin inversely associated with waist circumference (r = - 0.408, P < 0.01), triglyceride (r = -0.274, P < 0.05), ferritin (r = -0.260, P < 0.05), visceral fat (r = -0.248, P < 0.05), high sensitivity C-reactive protein (r = -0.228, P < 0.05) and body mass index (r = -0.225, P < 0.05). In multiple linear regression, waist circumference and high-density lipoprotein cholesterol were analyzed as independent variables of serum adiponectin.
CONCLUSION
Adiponectin concentrations were closely related to waist circumference in newly diagnosed type 2 diabetes.

Keyword

Adiponectin; Diabetes Mellitus; Type 2; Insulin Resistance

MeSH Terms

Adiponectin*
Adipose Tissue
Adiposity
Body Composition
Body Mass Index
C-Reactive Protein
Cholesterol
Cohort Studies
Diabetes Mellitus
Electric Impedance
Fasting
Ferritins
Glucose Tolerance Test
Humans
Insulin
Insulin Resistance
Intra-Abdominal Fat
Korea
Linear Models
Lipoproteins
Plasma*
Triglycerides
Waist Circumference
Adiponectin
C-Reactive Protein
Cholesterol
Ferritins
Insulin
Lipoproteins

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