J Korean Cancer Assoc.  2000 Jun;32(3):516-523.

Chemotherapy with Five-Day Continuous Infusion of 5-Fluorouracil (5-FU) Plus Cisplatin for Advanced Gastric Cancer; Significance of 5-FU Concentration Monitoring

• Park YH
• Kim BS
• Ryoo BY
• Kim TY
• Im YH
• Shin HS
• Kang YK

Abstract

PURPOSE: To investigate the therapeutic effects and toxicities of 5-day continuous infusion of 5-FU plus cisplatin FP chemotherapy in advanced gastric adendegrees Carcinoma and to elucidate the relationship between the pharmacokinetic (PK) parameters and therapeutic outcome.
MATERIALS AND METHODS
Patients with previously untreated advanced stomach cancer were treated with FP chemotherapy. Plasma concentrations of 5-FU were measured using gas chro matography method for 5 days. Correlation of PK parameters of 5-FU with clinical outcome after FP chemotherapy was studied.
RESULTS
Response rate of FP chemotherapy was 46% (95% C.I.: 30~62%). There was a wide range of difference in the concentration and area under the curve (AUC) of 5-FU from patient to patient. We could find significant differences in AUC of 5-FU between the responders and the non-responders (p<0.05).
CONCLUSION
We could confirm that FP chemotherapy was effective and tolerable for the treatment of advanced stomach cancer. The monitoring of plasma 5-FU concentration after chemotherapy and the adjustment of subsequent 5-FU dose seems to be necessary to improve the treatment outcome of FP chemotherapy.

Keyword

Stomach neoplasm; Continuous infusion; 5-FU; Pharmacokinetics

MeSH Terms

Area Under Curve
Cisplatin*
Drug Therapy*
Fluorouracil*
Humans
Pharmacokinetics
Plasma
Stomach Neoplasms*
Treatment Outcome
Cisplatin
Fluorouracil