Diabetes Metab J.  2013 Aug;37(4):252-261. 10.4093/dmj.2013.37.4.252.

Serum Adiponectin and Type 2 Diabetes: A 6-Year Follow-Up Cohort Study

Affiliations
  • 1Institute for Health Promotion, Department of Epidemiology and Health Promotion, Yonsei University Graduate School of Public Health, Seoul, Korea. jsunha@yuhs.ac
  • 2Division of Endocrinology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
  • 3Cardiovascular Center, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Korea.
  • 4Department of Laboratory Medicine, Yonsei University College of Medicine, Seoul, Korea.
  • 5Cardiology Division, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
  • 6Department of Food and Nutrition, Sungshin Women's University College of Human Ecology, Seoul, Korea.
  • 7Department of Endocrinology and Metabolism, Hanyang University College of Medicine, Seoul, Korea.
  • 8Department of Family Medicine, University of Ulsan College of Medicine, Seoul, Korea.
  • 9Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea.
  • 10Division of Cardiology, Department of Medicine, and Cardiac and Vascular Center, Center for Health Promotion, Sungkyunkwan University School of Medicine, Seoul, Korea.
  • 11Department of Endocrinology and Metabolism, Kyung Hee University School of Medicine, Seoul, Korea.
  • 12Division of Public Health Nutrition, Seoul National University School of Public Health and Institute of Health and Environment, Seoul, Korea.
  • 13Department of Endocrinology and Metabolism, The Catholic University of Korea College of Medicine, Seoul, Korea.
  • 14Division of Cardiology, Department of Internal Medicine, The Catholic University of Korea College of Medicine, Seoul, Korea.
  • 15Department of Family Medicine, Korea University College of Medicine, Seoul, Korea.
  • 16Department of Family Medicine, Ewha Womans University School of Medicine, Seoul, Korea.
  • 17National Health Insurance Service, Seoul, Korea.
  • 18Huh's Diabetes Center and the 21th Century Diabetes and Vascular Research Institute, Seoul, Korea.

Abstract

BACKGROUND
Studies on factors which may predict the risk of diabetes are scarce. This prospective cohort study was conducted to determine the association between adiponectin and type 2 diabetes among Korean men and women.
METHODS
A total of 42,845 participants who visited one of seven health examination centers located in Seoul and Gyeonggi province, Republic of Korea between 2004 and 2008 were included in this study. The incidence rates of diabetes were determined through December 2011. To evaluate the effects of adiponectin on type 2 diabetes, the Cox proportional hazard model was used.
RESULTS
Of the 40,005 participants, 959 developed type 2 diabetes during a 6-year follow-up. After the adjustment for age, body mass index (BMI), and waist circumference, the risks for type 2 diabetes in participants with normoglycemia had a 1.70-fold (95% confidence interval [CI], 1.21 to 2.38) increase in men and a 1.83-fold (95% CI, 1.17 to 2.86) increase in women with the lowest tertile of adiponectin when compared to the highest tertile of adiponectin. For participants with impaired fasting glucose (IFG), the risk for type 2 diabetes had a 1.46-fold (95% CI, 1.17 to 1.83) increase in men and a 2.52-fold (95% CI, 1.57 to 4.06) increase in women with the lowest tertile of adiponectin. Except for female participants with normoglycemia, all the risks remained significant after the adjustment for fasting glucose and other confounding variables. Surprisingly, BMI and waist circumference were not predictors of type 2 diabetes in men or women with IFG after adjustment for fasting glucose and other confounders.
CONCLUSION
A strong association between adiponectin and diabetes was observed. The use of adiponectin as a predictor of type 2 diabetes is considered to be useful.

Keyword

Adiponectin; Cohort studies; Diabetes mellitus; Impaired fasting glucose
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