J Korean Diabetes.  2014 Sep;15(3):142-145. 10.4093/jkd.2014.15.3.142.

The Role of the Kidney in Glucose Metabolism

• Rhee SY

• KMID: 2173884
• DOI: http://doi.org/10.4093/jkd.2014.15.3.142

Abstract

It is well known that the kidney is important for maintaining glucose homeostasis in vivo. However, the physiological role of the kidney in glucose metabolism is typically underestimated. Recently, a new class of anti-diabetic medications that affect the renal glucose regulatory mechanism was introduced into the market, sparking the interest of many researchers to better understand this mechanism. In this article, I briefly describe the role of the kidney in glucose metabolism and the changes of its function in patients with diabetes mellitus.

Keyword

Kidney; Glucose; Type 2 diabetes mellitus; Sodium glucose cotransporter 2; Gluconeogenesis

MeSH Terms

Diabetes Mellitus
Diabetes Mellitus, Type 2
Gluconeogenesis
Glucose*
Homeostasis
Humans
Kidney*
Metabolism*
Glucose

Figure

• 

  Fig. 1. Sodium glucose cotransporters (SGLTs) in the kidney. Adapted from Santer R, et al. Clin J Am Soc Nephrol 2010;5:133-41[12].

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