J Gynecol Oncol.  2010 Mar;21(1):56-58. 10.3802/jgo.2010.21.1.56.

Cellular fibroma of the ovary containing Leydig cell hyperplasia: a case report

Affiliations
  • 1Department of Obstetrics and Gynecology, CHA Gangnam Medical Center, CHA University, Seoul, Korea. sjseongcheil@yahoo.co.kr
  • 2Department of Pathology, CHA Gangnam Medical Center, CHA University, Seoul, Korea.

Abstract

Ovarian stromal tumors containing Leydig cell components are rare. Only a few cases of ovarian stromal Leydig cell tumors characterized by clusters of Leydig cells have been reported to date. Here, we present the first case report of a 65-year-old woman with a cellular fibroma of the ovary containing Leydig cell hyperplasia. Microscopic examination revealed the proliferation of spindle cells arranged in intersecting bundles with mild nuclear atypia and an average of 2-3 mitotic figures per ten high-power fields. Multifocal nests of polygonal cells with abundant eosinophilic cytoplasm and round nuclei were seen within the spindle cells. Final pathology of the tumor revealed a cellular fibroma including Leydig cell hyperplasia.

Keyword

Ovary; Fibroma; Leydig cells

MeSH Terms

Aged
Cellular Structures
Cytoplasm
Eosinophils
Female
Fibroma
Humans
Hyperplasia
Leydig Cell Tumor
Leydig Cells
Male
Ovary

Figure

  • Fig. 1 Cellular fibroma area showing a cellular proliferation of intersecting bundles of spindle cells with mild nuclear atypia. (A) ×100, (B) ×200.

  • Fig. 2 Multifocal areas of Leydig cell hyperplasia, consisting of nests of polygonal cells with abundant eosinophilic cytoplasm and round nuclei within the cellular fibroma. (A), (B) ×200.


Reference

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