J Gynecol Oncol.  2008 Sep;19(3):199-201. 10.3802/jgo.2008.19.3.199.

Adenocarcinoma arising in mature cystic teratoma: a case report

Affiliations
  • 1Department of Obstetrics and Gynecology, Korea University Anam Hospital, Korea University College of Medicine, Seoul, Korea. pumplee@korea.ac.kr
  • 2Department of Obstetrics and Gynecology, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Korea.
  • 3Department of Obstetrics and Gynecology, Korea University Ansan Hospital, Korea University College of Medicine, Ansan, Korea.

Abstract

Benign cystic teratoma is recognized as one of the most common tumors in women during the reproductive age and frequently is treated by pelviscopic operation. Malignant transformation of a benign cystic teratoma is a rare event, and adenocarcinoma is extremely rare, and distinguishing this malignant change from benign disease preoperatively is nearly impossible even by the use of radiological imaging or various tumor markers. Therefore, patients should be informed that if a laparoscopic cystectomy is undertaken, a prompt second staging operation should be performed if the definitive pathology reveals an unexpected malignancy. We present a case with thyroid papillary carcinoma of follicular variant arising from mature cystic teratoma removed by laparoscopic salpingo-oophorectomy followed by staging laparotomy. We briefly reviewed literatures with regard to malignant transformation of a benign cystic teratoma.

Keyword

Mature cystic teratoma; Malignant transformation; Adenocarcinoma; Tumor marker

MeSH Terms

Adenocarcinoma
Carcinoma, Papillary
Cystectomy
Female
Humans
Laparotomy
Teratoma
Thyroid Gland
Biomarkers, Tumor

Figure

  • Fig. 1 (A) Follicular variant papillary carcinoma, nuclear clearing, nuclear groove irregular nuclei (H&E; ×40). (B) In the ovarian tumor, there is a lesion of well formed follicles of thyroid gland (H&E; ×400).


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