Chonnam Med J.  2012 Aug;48(2):123-127. 10.4068/cmj.2012.48.2.123.

Clinical Effect of a Mixed Solution of Sodium Hyaluronate and Sodium Carboxymethylcellulose During the Transconjunctival Approach for Orbital Wall Reconstruction

• Kang BW
• Lee HS
• Oh HJ
• Yoon KC

• KMID: 2172214
• DOI: http://doi.org/10.4068/cmj.2012.48.2.123

Abstract

This study aimed to evaluate the anti-adhesive effect of a mixed solution of sodium hyaluronate and sodium carboxymethylcellulose (HACMC, Guardix-sol(R)) during the transconjunctival approach to orbital wall reconstruction. Eighty-seven patients who underwent orbital wall reconstruction by the transconjunctival approach were enrolled in this prospective study. We applied HACMC between the orbicularis oculi muscle and the orbital septum after surgery in 47 patients and did not use it in 40 patients. Lower lid retraction and marginal reflex distance 2 (MRD2) were measured to analyze the degree of postoperative adhesion at 1 week and 1, 3, and 6 months. The degree of MRD2 showed clinically significant differences at postoperative 1 week and 1 month between the HACMC and control groups (p<0.05). Lower lid ectropion developed in two patients (5.0%) in the control group but did not occur in the HACMC group. In orbital wall reconstruction by the transconjunctival approach, the HACMC mixture solution is effective for preventing adhesion and lower lid ectropion during the early postoperative period.

Keyword

Eyelid retraction; Eyelids; Orbital fractures

MeSH Terms

Carboxymethylcellulose Sodium
Ectropion
Eyelids
Humans
Hyaluronic Acid
Muscles
Orbit
Orbital Fractures
Postoperative Period
Prospective Studies
Reflex
Sodium
Carboxymethylcellulose Sodium
Hyaluronic Acid
Sodium

Figure

• 

  FIG. 1 Comparison of the amount of enophthalmos (A), limitation of motion (B), diplopia (C) and marginal reflex distance2 (D) between the HACMC and control groups. *Significant at p<0.05 compared with control group. HACMC: the mixed solution of sodium hyaluronate and sodium carboxymethylcellulose (Guardix-sol®).

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