Chonnam Med J.  2014 Dec;50(3):82-85. 10.4068/cmj.2014.50.3.82.

Use of Umbilical Cord Serum in Ophthalmology

• Yoon KC

• KMID: 2172150
• DOI: http://doi.org/10.4068/cmj.2014.50.3.82

Abstract

Among blood preparations, serum has been topically used in the management of various ocular diseases in ophthalmology. Like peripheral blood serum, umbilical cord blood serum contains a high concentration of essential tear components, growth factors, neurotrophic factors, vitamin A, fibronectin, prealbumin, and oil. Umbilical cord serum can provide basic nutrients for epithelial renewal and can facilitate the proliferation, migration, and differentiation of the ocular surface epithelium. Eye drops made from umbilical cord serum have been applied to treat various ocular surface diseases, including severe dry eye with or without Sjogren's syndrome, ocular complications in graft-versus-host disease, persistent epithelial defects, neurotrophic keratopathy, recurrent corneal erosions, ocular chemical burn, and surface problems after corneal refractive surgery. Because mesenchymal stem cells from umbilical cord blood can be used to regenerate corneal tissue and retinal nerve cells, umbilical cord serum might be applied for tissue engineering and regenerative medicine in the future.

Keyword

Ophthalmology; Umbilical cord; Serum; Dry eye

MeSH Terms

Burns, Chemical
Epithelium
Fetal Blood
Fibronectins
Graft vs Host Disease
Intercellular Signaling Peptides and Proteins
Mesenchymal Stromal Cells
Nerve Growth Factors
Neurons
Ophthalmic Solutions
Ophthalmology*
Prealbumin
Refractive Surgical Procedures
Regenerative Medicine
Retinaldehyde
Serum
Sjogren's Syndrome
Tears
Tissue Engineering
Umbilical Cord*
Vitamin A
Fibronectins
Intercellular Signaling Peptides and Proteins
Nerve Growth Factors
Ophthalmic Solutions
Prealbumin
Retinaldehyde
Vitamin A

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