Ann Dermatol.  2011 Feb;23(1):104-107. 10.5021/ad.2011.23.1.104.

CD8+ Lymphomatoid Papulosis

• Sim JH
• Kim YC

• KMID: 2171966
• DOI: http://doi.org/10.5021/ad.2011.23.1.104

Abstract

Lymphomatoid papulosis (LyP) is defined as a histologically malignant, but clinically benign condition. It can appear as erythematous pink to purple papules or nodules. Immunophenotyping studies of the lymphomatoid papulosis lesions have shown a predominance of a CD4 expression and negativity for CD8. However, a positive CD8 expression has rarely been reported for LyP. Herein we report on a case of CD8 positive lymphomatoid papulosis in a 43-year-old man. The patient presented with erythematous, asymptomatic papules on the left axilla and thigh. Histopathologically, there was a wedge-shaped infiltrate composed of a mixture of various cell types, including lymphocytes, histiocytes, neutrophils and large atypical lymphoid cells. Immunophenotyping revealed the neoplastic cells were positive for CD3, CD8 and CD30 and they were negative for CD4, CD20 and CD56.

Keyword

CD8+; Lymphomatoid papulosis

MeSH Terms

Adult
Axilla
Histiocytes
Humans
Immunophenotyping
Lymphocytes
Lymphomatoid Papulosis
Neutrophils
Thigh

Figure

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  Fig. 1 Erythematous papules with crust on the left axilla (A) and thigh (B).

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  Fig. 2 A wedge-shaped infiltrate that is composed of a mixture of various cell types, including lymphocytes, histiocytes, neutrophils and various atypical large lymphoid cells (A: left axilla, H&E, ×100; B: thigh, H&E, ×200).

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  Fig. 3 Immunophenotyping revealed the cell population to be predominantly negative for CD4 (A: left axilla, ×100) and positive for CD8 on the left axilla (B: ×100) and thigh (C: ×100) and the cells are positive for CD30 (D: thigh, ×100).

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