Ann Dermatol.  2011 Feb;23(1):73-75. 10.5021/ad.2011.23.1.73.

Pigmented Mammary Paget Disease with Reticulated Features: A Rare Variant of Mammary Paget Disease

• Lee EA
• Kim HS
• Kim HO
• Park YM

• KMID: 2171957
• DOI: http://doi.org/10.5021/ad.2011.23.1.73

Abstract

Pigmented mammary Paget disease (PMPD) is a rare subtype of mammary Paget disease that presents as a hyperpigmented patch or plaque over the areola and nipple. We herein report on an unusual case of PMPD with reticulated features in a 98-year-old female. The histology showed intraepidermal pagetoid cells containing melanin pigments without any underlying intraductal carcinoma.

Keyword

Pigmented mammary Paget disease; Reticulated pattern

MeSH Terms

Carcinoma, Intraductal, Noninfiltrating
Female
Humans
Melanins
Nipples
Paget's Disease, Mammary
Melanins

Figure

• 

  Fig. 1 Dark brownish colored reticulated plaque on the left breast and nipple.

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  Fig. 2 Large clear cells with vesicular nuclei are dispersed in the suprabasal layers of the epidermis. Some clear cells contain intracytoplasmic melanin pigments (A: H&E, ×400). Immunohistochemical staining of Paget cells (B: anticytokeratin 7, C: CEA, D: S-100 protein and E: HMB-45, ×400).

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