Ann Dermatol.  2011 Dec;23(Suppl 3):S380-S382. 10.5021/ad.2011.23.S3.S380.

A Case of Celecoxib Induced Acute Generalized Exanthematous Pustulosis

• Shin HT
• Park SW
• Lee KT
• Park HY
• Park JH
• Lee DY
• Lee JH
• Yang JM
• Lee ES

• KMID: 2171877
• DOI: http://doi.org/10.5021/ad.2011.23.S3.S380

Abstract

Acute generalized exanthematous pustulosis (AGEP) is manifested by rapid development of many sterile, nonfollicular pustules on a background of edematous erythema. More than 90 percent of AGEP are induced by medication, mostly antibiotics. Drug patch test can be helpful in the diagnosis of AGEP. This paper reports the first case of celecoxib-induced AGEP confirmed by patch test in Korean literature.

Keyword

Acute generalized exanthematous pustulosis; Celecoxib; Patch test

MeSH Terms

Acute Generalized Exanthematous Pustulosis
Anti-Bacterial Agents
Erythema
Patch Tests
Pyrazoles
Sulfonamides
Celecoxib
Anti-Bacterial Agents
Pyrazoles
Sulfonamides

Figure

• 

  Fig. 1 (A) Numerous tiny nonfollicular pustules on the face. (B) A hundred of non-follicular pustules on the back.

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  Fig. 2 (A) Subconeal pustules in the epidermis (H&E, ×200). (B) Perivascular infiltration of lymphocytes and eosinophils in the upper dermis (H&E, ×400).

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  Fig. 3 Strong vesicular reaction to celecoxib diluted at 5% in normal saline after 48 hours.

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