Ann Dermatol.  2011 Dec;23(Suppl 3):S288-S289. 10.5021/ad.2011.23.S3.S288.

Acute Generalized Exanthematous Pustulosis Caused by Daptomycin

Affiliations
  • 1Department of Dermatology, Changi General Hospital, Singapore 529889, Singapore. docmark@pacific.net.sg
  • 2Department of Pathology, Singapore General Hospital, Singapore 169608, Singapore.

Abstract

Daptomycin, a lipopeptide antibiotic with similar action as vancomycin, is used to treat complicated skin and soft tissue infections caused by resistant Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus, penicillin-resistant streptococci, and vancomycin-resistant enterococci. Acute generalized exanthematous pustulosis (AGEP), characterized by acute onset of numerous sterile, nonfollicular pinhead sized pustules, is common secondary to drugs, in particular, antibiotics. We present the first case of AGEP following the use of daptomycin.

Keyword

Acute generalized exanthematous pustulosis; Daptomycin

MeSH Terms

Acute Generalized Exanthematous Pustulosis
Anti-Bacterial Agents
Daptomycin
Gram-Positive Bacteria
Methicillin-Resistant Staphylococcus aureus
Skin
Soft Tissue Infections
Vancomycin
Anti-Bacterial Agents
Daptomycin
Vancomycin

Figure

  • Fig. 1 Histology shows subcorneal pustules with perivascular lymphoplasmacytic infiltrates admixed with neutrophils and occasional eosinophils (H&E, ×100).


Reference

1. Carpenter CF, Chambers HF. Daptomycin: another novel agent for treating infections due to drug-resistant gram-positive pathogens. Clin Infect Dis. 2004. 38:994–1000.
Article
2. Streit JM, Jones RN, Sader HS. Daptomycin activity and spectrum: a worldwide sample of 6737 clinical Gram-positive organisms. J Antimicrob Chemother. 2004. 53:669–674.
Article
3. Lerch M, Bircher AJ. Systemically induced allergic exanthem from mercury. Contact Dermatitis. 2004. 50:349–353.
Article
4. Haro-Gabaldón V, Sánchez-Sánchez-Vizcaino J, Ruiz-Avila P, Gutiérrez-Fernández J, Linares J, Naranjo-Sintes R. Acute generalized exanthematous pustulosis with cytomegalovirus infection. Int J Dermatol. 1996. 35:735–737.
Article
5. Sidoroff A, Dunant A, Viboud C, Halevy S, Bavinck JN, Naldi L, et al. Risk factors for acute generalized exanthematous pustulosis (AGEP)-results of a multinational case-control study (EuroSCAR). Br J Dermatol. 2007. 157:989–996.
Article
Full Text Links
  • AD
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr