Ann Dermatol.  2013 May;25(2):271-272. 10.5021/ad.2013.25.2.271.

Epoprostenol: Flushing or Erythroderma?

Affiliations
  • 1Department of Dermatology, University General Hospital of Albacete, Faculty of Medicine, University of Castilla-La Mancha, Albacete, Spain. mlmartinezm@sescam.jccm.es
  • 2Department of Pneumology, University General Hospital of Albacete, Faculty of Medicine, University of Castilla-La Mancha, Albacete, Spain.
  • 3Department of Pathology, University General Hospital of Albacete, Faculty of Medicine, University of Castilla-La Mancha, Albacete, Spain.
  • 4Department of Cardiology, University General Hospital of Albacete, Faculty of Medicine, University of Castilla-La Mancha, Albacete, Spain.

Abstract

No abstract available.


MeSH Terms

Flushing

Figure

  • Fig. 1 Severe erythroderma associated with intravenous epoprostenol therapy. The patient presented her skin diffusely erythematous with accentuation on the extremities with large areas of exfoliation.

  • Fig. 2 Epidermis with focal parakeratosis and superficial perivascular mononuclear infiltrate with occasional exocytosis of lymphocytes associated with spongiosis and eosinophils (H&E stain; A: ×10, B: ×40).


Reference

1. Barst RJ, Rubin LJ, Long WA, McGoon MD, Rich S, Badesch DB, et al. Primary Pulmonary Hypertension Study Group. A comparison of continuous intravenous epoprostenol (prostacyclin) with conventional therapy for primary pulmonary hypertension. N Engl J Med. 1996. 334:296–301.
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2. Badesch DB, Tapson VF, McGoon MD, Brundage BH, Rubin LJ, Wigley FM, et al. Continuous intravenous epoprostenol for pulmonary hypertension due to the scleroderma spectrum of disease. A randomized, controlled trial. Ann Intern Med. 2000. 132:425–434.
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3. McLaughlin VV, Shillington A, Rich S. Survival in primary pulmonary hypertension: the impact of epoprostenol therapy. Circulation. 2002. 106:1477–1482.
4. Myers SA, Ahearn GS, Angelica Selim M, Tapson VF. Cutaneous findings in patients with pulmonary arterial hypertension receiving long-term epoprostenol therapy. J Am Acad Dermatol. 2004. 51:98–102.
Article
5. Ahearn GS, Selim MA, Tapson VF. Severe erythroderma as a complication of continuous epoprostenol therapy. Chest. 2002. 122:378–380.
Article
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