Ann Dermatol.  2014 Apr;26(2):256-258. 10.5021/ad.2014.26.2.256.

Expression of Cold-Inducible RNA-Binding Protein in Normal Skin, Actinic Keratosis and Squamous Cell Carcinoma

• Park BM
• Lee JH
• Kim SJ

• KMID: 2171666
• DOI: http://doi.org/10.5021/ad.2014.26.2.256

Abstract

No abstract available.

MeSH Terms

Carcinoma, Squamous Cell*
Keratosis, Actinic*
RNA-Binding Proteins*
Skin*
RNA-Binding Proteins

Figure

• 

  Fig. 1 Cold-inducible RNA-binding protein (CIRP) expression is evident in the nuclei of epidermal keratinocytes in normal skin from back (CIRP immunohistochemical stain, ×200).

• 

  Fig. 2 Expression patterns of Cold-inducible RNA-binding protein (CIRP). Representative pictures of five cases in each normal skin from face (A), actinic keratosis (AK) (B), and squamous cell carcinoma (SCC) (C) (A~C: CIRP immunohistochemical stain, ×200). Inset: higher magnification of the hot spot of the specimen (CIRP immunohistochemical stain, ×400). (D) Statistical analysis of staining intensity shows significantly decreased nuclear CIRP expression in actinic keratosis and squamous cell carcinoma compared with normal skin specimens. Open circles: tissue sample from back. Closed circle: tissue sample from face. Open circle indicates a normal skin specimen from the back. *p<0.05, **p<0.01, Wilcoxon's rank sum test.

Reference

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