Ann Dermatol.  2014 Apr;26(2):254-255. 10.5021/ad.2014.26.2.254.

Foreign Body Granuloma Secondary to Leuprorelin Acetate

• Lee BI
• Lee JY
• Kim HO
• Park YM

• KMID: 2171665
• DOI: http://doi.org/10.5021/ad.2014.26.2.254

Abstract

No abstract available.

MeSH Terms

Granuloma, Foreign-Body*
Leuprolide*
Leuprolide

Figure

• 

  Fig. 1 Three, pruritic, 2~3-cm, erythematous nodules at the site of a previous leuprorelin injection on the left upper arm.

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  Fig. 2 Histopathology of skin lesions. (A) An acanthotic epidermis with a marked degeneration of adipocytes, and an intense inflammatory cell infiltrate, composed of lymphocytes and neutrophils. (B) Foreign-body-type giant cells with translucent intracytoplasmic vacuoles (arrows) (H&E; Inset: ×100, A: ×40, B: ×400).

Reference

1. Yasukawa K, Sawamura D, Sugawara H, Kato N. Leuprorelin acetate granulomas: case reports and review of the literature. Br J Dermatol. 2005; 152:1045–1047.

2. Ouchi T, Koyama T, Miyata N, Sugiura M. Granuloma caused by subcutaneous injection of leuprorelin acetate product: case report and histopathological findings. J Dermatol. 2006; 33:719–721.

3. Shiota M, Tokuda N, Kanou T, Yamasaki H. Incidence rate of injection-site granulomas resulting from the administration of luteinizing hormone-releasing hormone analogues for the treatment of prostatic cancer. Yonsei Med J. 2007; 48:421–424.

4. Watanabe T, Yamada N, Yoshida Y, Yamamoto O. A morphological study of granulomas induced by subcutaneous injection of leuprorelin acetate. J Cutan Pathol. 2009; 36:1299–1302.