J Cancer Prev.  2015 Mar;20(1):12-24. 10.15430/JCP.2015.20.1.12.

Endocrine-disrupting Chemicals: Review of Toxicological Mechanisms Using Molecular Pathway Analysis

• Yang O
• Kim HL
• Weon JI
• Seo YR

• KMID: 2171314
• DOI: http://doi.org/10.15430/JCP.2015.20.1.12

Abstract

Endocrine disruptors are known to cause harmful effects to human through various exposure routes. These chemicals mainly appear to interfere with the endocrine or hormone systems. As importantly, numerous studies have demonstrated that the accumulation of endocrine disruptors can induce fatal disorders including obesity and cancer. Using diverse biological tools, the potential molecular mechanisms related with these diseases by exposure of endocrine disruptors. Recently, pathway analysis, a bioinformatics tool, is being widely used to predict the potential mechanism or biological network of certain chemicals. In this review, we initially summarize the major molecular mechanisms involved in the induction of the above mentioned diseases by endocrine disruptors. Additionally, we provide the potential markers and signaling mechanisms discovered via pathway analysis under exposure to representative endocrine disruptors, bisphenol, diethylhexylphthalate, and nonylphenol. The review emphasizes the importance of pathway analysis using bioinformatics to finding the specific mechanisms of toxic chemicals, including endocrine disruptors.

Keyword

Endocrine disruptors; Molecular mechanism; Obesogen; Pathway analysis

MeSH Terms

Computational Biology
Endocrine Disruptors
Humans
Obesity
Endocrine Disruptors