Clin Psychopharmacol Neurosci.  2011 Apr;9(1):23-28.

Clinical Predictors of Drug Response in Patients with Obsessive-Compulsive Disorder

  • 1Department of Psychiatry, Severance Mental Health Hospital, Yonsei University, Gwangju, Korea.
  • 2Department of Psychiatry, Kwandong University College of Medicine, Goyang, Korea.
  • 3Department of Psychiatry, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
  • 4Department of Psychiatry, Gangnam Cha University College of Medicine, Seoul, Korea.
  • 5Department of Psychiatry, Yongin Mental Health Hospital, Yongin, Korea.


The aim of this study was to evaluate which clinical variables might influence the antiobsessional responses to proserotonergic drugs in a sample of patients with obsessive-compulsive disorder (OCD).
Two hundred forty-nine patients with DSM-IV OCD under-gone mean 13-month treatments with selective serotonin reuptake inhibitors. According to the treatment response, defined as a reductions of the Yale-Brown Obsessive Compulsive Scale (Y-BOCS) total score > or =35%, patients were divided into two groups.
One hundred fourteen patients responded to the treatment and the other one hundred thirty five patients did not. Responders had a significant long duration of medication in YUMC OCD clinic, short total duration of past treatment in other institutes, and higher frequency of drug naive cases and lower baseline Y-BOCS scores.
The pre-treatment factors including total duration of past treatment, drug naive or not, baseline OCD symptoms and the factor of duration of the treatment may influence drug treatment response in OCD patients.


Obsessive-compulsive disorder; Clinical predictors; Drug response; Treatment duration
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