Clin Psychopharmacol Neurosci.  2015 Aug;13(2):174-179. 10.9758/cpn.2015.13.2.174.

Comparison of the Effects of a Brand-name Drug and Its Generic Drug on the Quality of Life of Alzheimer's Disease Patients

Affiliations
  • 1NPO Japanese Drug Organization of Appropriate Use and Research, Japan. sakakibara606@gmail.com
  • 2Sugi Pharmacy Co., Ltd., Japan.
  • 3Pharmaceutical Hospital Laboratory, Faculty of Pharmacy, Meijo University, Nagoya, Japan.
  • 4Department of Regional Pharmaceutical Care and Sciences, Faculty of Pharmacy, Meijo University, Nagoya, Japan.
  • 5Department of Drug Policy and Management, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan.

Abstract


OBJECTIVE
The pharmacological effects of generic (GE) donepezil are the same as Aricept, its brand-name counterpart. However, little is known as to whether these two drugs provide the same quality of life (QOL). The study subjects were patients with Alzheimer's disease who were taking donepezil hydrochloride tablets, and were selected by visiting either the local pharmacies or the patients' homes. We chose the brand-name drug Aricept and its GE form donepezil to investigate, from a long-term caregiver's perspective, the influence of both drugs on the patients' QOL.
METHODS
An EuroQol-5 Dimension (EQ-5D) was used to assess the QOL of patients with Alzheimer's disease, before and after various Aricept and/or donepezil regimens. Patients were divided into four groups: first time users of Aricept (n=43), first time users of GE donepezil (n=45), users refilling previous prescriptions of Aricept (n=51), and users switching from Aricept to GE donepezil (n=51).
RESULTS
The average change in the EQ-5D utility indices rose significantly in the patients starting a new regimen of Aricept and its GE drug. The patients continuing an existing regimen of Aricept showed no significant differences, even after Aricept was switched to a GE drug.
CONCLUSION
The QOL of patients starting a new regimen of Aricept and its GE drug improved. The QOL was maintained upon switching to the GE drug form.

Keyword

Alzheimer disease; Donepezil hydrochloride; Generic drugs; Quality of life; EuroQol-5 Dimension
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