Clin Psychopharmacol Neurosci.  2015 Dec;13(3):256-262. 10.9758/cpn.2015.13.3.256.

Gender Differences in the Clinical Characteristics of Psychotic Depression: Results from the CRESCEND Study

  • 1Department of Psychiatry, Yong-In Mental Hospital, Yongin, Korea.
  • 2Institute of Mental Health, Hanyang University, Seoul, Korea.
  • 3Department of Clinical Medicine, Aarhus University Hospital, Risskov, Denmark.
  • 4The Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPsych), Denmark.
  • 5Department of Psychiatry, Chonnam National University School of Medicine, Gwangju, Korea.
  • 6Department of Psychiatry, College of Medicine, The Catholic University of Korea, Seoul, Korea.
  • 7Department of Psychiatry, Korea University College of Medicine, Seoul, Korea.
  • 8Department of Psychiatry, Keimyung University School of Medicine, Daegu, Korea.
  • 9Department of Preventive Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea.
  • 10Department of Psychiatry, Hanyang University Guri Hospital, Hanyang University College of Medicine, Guri, Korea.


To test whether there are gender differences in the clinical characteristics of patients with psychotic depression (PD).
Using data from the Clinical Research Center for Depression (CRESCEND) study in South Korea, we tested for potential gender differences in clinical characteristics among 53 patients with PD. The Psychotic Depression Assessment Scale (PDAS) and other psychometric scales were used to evaluate various clinical features of the study subjects. Independent t-tests were performed for normally distributed variables, Mann-Whitney U-tests for non-normally distributed variables, and chi2 tests for discrete variables. In addition, to exclude the effects of confounding variables, we carried out an analysis of covariance (ANCOVA) for the normally distributed variables and binary logistic regression analyses for discrete variables, after adjusting the effects of marital status.
We identified more prevalent suicidal ideation (adjusted odds ratio [aOR]=10.316, p=0.036) and hallucinatory behavior (aOR=8.332, p=0.016), as well as more severe anxiety symptoms (degrees of freedom [df]=1, F=6.123, p=0.017), and poorer social and occupational functioning (df=1, F=6.265, p=0.016) in the male patients compared to the female patients.
Our findings suggest that in South Korean patients with PD, suicidal ideation, hallucinatory behavior, and anxiety is more pronounced among males than females. This should be taken into consideration in clinical practice.


Psychotic depression; Gender; Suicidal ideation; Hallucinatory behavior; Illness burden
Full Text Links
  • CPN
  • Twitter
  • Facebook
Copyright © 2020 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: