Clin Psychopharmacol Neurosci.  2016 May;14(2):221-225. 10.9758/cpn.2016.14.2.221.

Acute Dystonia Following a Switch in Treatment from Atomoxetine to Low-dose Aripiprazole

  • 1Department of Child and Adolescent Psychiatry, School of Medicine, Pamukkale University, Denizli, Turkey.
  • 2Department of Child and Adolescent Psychiatry, School of Medicine, Ege University, Izmir, Turkey.


The present report describes the cases of a 17-year-old male patient and a 13-year-old female patient who developed acute dystonia following the administration of low-dose aripiprazole (5 mg/day) after the cessation of atomoxetine treatment. Although aripiprazole-induced dystonia has been previously reported in the literature, it is rare, and most of these cases were associated with doses higher than 5 mg/day. Furthermore, both of the patients in the present study discontinued atomoxetine prior to the initiation of aripiprazole treatment; thus, this report also discussed the possible mechanisms underlying the manifestation of dystonia from the perspective of neurotransmitter activity.


Aripiprazole; Atomoxetine; Dystonia
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