Biomol Ther.  2016 Jan;24(1):67-74. 10.4062/biomolther.2015.070.

Inhibition of Lung Inflammation by Acanthopanax divaricatus var. Albeofructus and Its Constituents

Affiliations
  • 1College of Pharmacy, Kangwon National University, Chuncheon 24341, Republic of Korea. hpkim@kangwn.ac.kr
  • 2College of Pharmacy, Chungnam National University, Daejeon 34134, Republic of Korea.
  • 3College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.

Abstract

In order to find potential therapeutic agents on lung inflammatory conditions, the extracts of Acanthopanax divaricatus var. albeofructus were prepared and its constituents were isolated. They include lignans such as (+)-syringaresinol (1), acanthoside B (2), salvadoraside (3) and acanthoside D (4), lariciresinol-9-O-beta-D-glucopyranoside (5) and phenylpropanoids such as 4-[(1E)-3-methoxy-1-propenyl]phenol (6), coniferin (7), and methyl caffeate (8). The extracts and several constituents such as compound 1, 6 and 8 inhibited the production of inflammatory markers, IL-6 and nitric oxide, from IL-1beta-treated lung epithelial cells and lipopolysaccharide (LPS)-treated alveolar macrophages. Furthermore, the extracts and compound 4 significantly inhibited lung inflammation in lipolysaccharide-treated acute lung injury in mice by oral administration. Thus it is suggested that A. divaricatus var. albeofructus and its several constituents may be effective against lung inflammation.

Keyword

Acantopanax divaricatus var. albeofructus; Lung inflammation; Acanthoside; Macrophage
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