Infect Chemother.  2007 Dec;39(6):327-331.

A Case of Esophageal Aspergillosis Developed in Patient with Rheumatoid Arthritis

Affiliations
  • 1Department of Internal Mdicine, Ewha Womans University, School of Medicine, Seoul, Korea. heechoi@ewha.ac.kr
  • 2Department of Internal Mdicine, Kosin University College of Medicine, Busan, Korea.
  • 3Department of Pathology, Ewha Womans University, School of Medicine, Seoul, Korea.

Abstract

Invasive fungal infections contribute substantially to death and illness. Invasive aspergillosis usually occurs in immunocompromised patients and is associated with high morbidity and mortality. Primary infection usually involves the respiratory tract following environmental exposure to Aspergillus and may, in severely immunocompromised patients, disseminate to other organs. A 35-year-old woman with history of rheumatoid arthritis for more than 10 years, developed dysphagia for 2 months following the combination therapy with prednisolone and etanercept. The patient was hospitalized and diagnosed as esophageal aspergillosis by gastroduodenoscopic biopsy. Fourteen days after initiation of itraconazole, dysphagia recovered completely. It is very rare case to develop only esophageal aspergillosis without invasion of any other organs. We report here, the case of localized aspergillosis in patient who took immunosuppressants for rheumatoid arthritis.

Keyword

Aspergillosis; Esophagitis; Immunocompromised; Etanercept

MeSH Terms

Adult
Arthritis, Rheumatoid*
Aspergillosis*
Aspergillus
Biopsy
Deglutition Disorders
Environmental Exposure
Etanercept
Esophagitis
Female
Humans
Immunocompromised Host
Immunosuppressive Agents
Itraconazole
Mortality
Prednisolone
Respiratory System
Immunosuppressive Agents
Itraconazole
Prednisolone
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