J Biomed Res.  2014 Mar;15(1):40-43.

Probiotic dietary supplementation in a dog with chronic kidney disease

• Jo S
• Kang M
• Lee K
• Lee C
• Kim S
• Park S
• Kim T
• Park H

Abstract

A 7-year-old spayed female English Cocker Spaniel dog presented with polyuria (PU), polydipsia (PD), intermittent vomiting, and weight loss. Physical examination revealed pale, tacky mucous membranes and severe emaciation. Hematological and biochemical examinations revealed moderate normocytic normochromic non-regenerative anemia and moderate azotemia. Abdominal ultrasonography demonstrated bilaterally small lumpy-bumpy kidneys with hyperechoic parenchyma as well as loss of renal corticomedullary junction. Based on clinical history and examinations, the dog was diagnosed with chronic kidney disease (CKD). The dog was treated with supportive care including fluid therapy, phosphate-binding agent, and histamine H2-receptor antagonist. Darbepoetin Alfa was administered to control renal secondary non-regenerative anemia. Prescribed diet with low-protein and low-phosphorus was fed to alleviate CKD signs. Further, dietary probiotics were supplemented. This case demonstrates that oral probiotic supplementation helped reduce blood urea-nitrogen (BUN) levels. This case indicates that dietary probiotics can be a potential alternative therapeutic agent for management of renal failure.

Keyword

azotemia; chronic kidney disease; dietary probiotics; dog; kidney function

MeSH Terms

Anemia
Animals
Azotemia
Child
Darbepoetin alfa
Diet
Dietary Supplements*
Dogs*
Emaciation
Female
Fluid Therapy
Histamine
Humans
Kidney
Mucous Membrane
Physical Examination
Polydipsia
Polyuria
Probiotics*
Renal Insufficiency
Renal Insufficiency, Chronic*
Ultrasonography
Vomiting
Weight Loss
Histamine