J Bacteriol Virol.  2015 Mar;45(1):44-50. 10.4167/jbv.2015.45.1.44.

Intranasal Administration Model for Evaluating Protection Against Influenza Virus in Mice

  • 1Avian Disease Laboratory, College of Veterinary Medicine, Konkuk University, Seoul, Korea. songcs@konkuk.ac.kr
  • 2GENEBIOTECH CO., LTD, 166 Sinwonsa-ro, Gyeryong-myeon, Gongju-si, Chungcheongnam-do, Korea.


Antiviral activity against Influenza virus of 14 Lactobacillus species isolated from food was monitored. Lactobacillus species were isolated from traditional Korean fermented food. Each live Lactobacillus was administered into the nasal cavity of SPF 6-week-old BALB/c mice. After the Lactobacillus treatment, Influenza virus (A/NWS/33/H1N1) was inoculated to each mouse. Clinical signs and mortality was monitored for 21 days. Each Lactobacillus strain showed various level of antiviral activity against Influenza virus. As a result of this study, this mouse experiment model, including intranasal treatment of live Lactobacillus species, could be effective model in evaluating immunomodulatory response of probiotics against respiratory viruses.


Animal model; Probiotics; Influenza; Antiviral
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